interstitial
adjective
in·ter·sti·tial
ˌin-tər-ˈsti-shəl 
1
: occurring in or being an interval or intervening space or segment : of, relating to, or forming an interstice
an interstitial space
… the site has been running interstitial ads, which consist of a full page of advertising between editorial pages, for a little more than a year.—
Carl Sullivan
Carl Sullivan2
a
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
b
: affecting the interstitial tissues of an organ or part
interstitial cystitis
3
: being or relating to a crystalline compound in which usually small atoms or ions of a nonmetal occupy holes between the larger metal atoms or ions in the crystal lattice
Examples of interstitial in a Sentence
Recent Examples on the Web
According to Johnson, certain probiotics produce short-chain fatty acids that stimulate the interstitial muscles to move food in the GI tract.
—Maggie O'Neill, Verywell Health, 12 May 2025
At a press screening of the film in March, these cute, interstitial clips drew big laughs.
—Eric Renner Brown, Billboard, 7 May 2025
In addition to those interstitial car-ride scenes, the movie relies heavily on archival interview footage (Cheech & Chong interviewed by Geraldo Rivera, Cheech & Chong at the Playboy Mansion, etc.).
—Adam Tschorn, Los Angeles Times, 23 Apr. 2025
An alternative approach is to sample lactate in interstitial fluid, which mirrors blood levels more reliably, using a slender filament that pokes through the skin.
—Alex Hutchinson, Outside Online, 25 Nov. 2024
See All Example Sentences for interstitial
Examples are automatically compiled from online sources to
show current usage.
Read More
Opinions expressed in the examples do not represent those of Merriam-Webster or its editors.
Send us feedback.
Maggie O'Neill, Verywell Health, 12 May 2025
At a press screening of the film in March, these cute, interstitial clips drew big laughs.
—Eric Renner Brown, Billboard, 7 May 2025
In addition to those interstitial car-ride scenes, the movie relies heavily on archival interview footage (Cheech & Chong interviewed by Geraldo Rivera, Cheech & Chong at the Playboy Mansion, etc.).
—Adam Tschorn, Los Angeles Times, 23 Apr. 2025
An alternative approach is to sample lactate in interstitial fluid, which mirrors blood levels more reliably, using a slender filament that pokes through the skin.
—Alex Hutchinson, Outside Online, 25 Nov. 2024
See All Example Sentences for interstitial
Cite this Entry
“Interstitial.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/interstitial. Accessed 18 May. 2025.
Copy CitationKids Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
: relating to or located in the interstices
Medical Definition
interstitial
adjective
in·ter·sti·tial
ˌint-ər-ˈstish-əl
1
: situated within but not restricted to or characteristic of a particular organ or tissue
—used especially of fibrous tissue
2
: affecting the interstitial tissues of an organ or part
interstitial hepatitis
3
: occurring in the part of a fallopian tube in the wall of the uterus
interstitial pregnancy
Love words? Need even more definitions?
Merriam-Webster unabridged
Share